Application

Research CategoryApoptosis & Cancer

This Anti-Cathepsin Z antibody is validated for use in Western Blotting for the detection of Cathepsin Z.

Research Sub CategoryApoptosis - Additional

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Cathepsin Z, also known as Cathepsin P, Cathepsin X, and encoded by the gene name CTSZ, is a member of the the peptidase C1 family. Cathepsin Z is a lysosomal cysteine proteinase that exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities. Cathepsin Z is expressed ubiquitously in cancer cell lines and primary tumors and, like other members of this family, may be involved in tumorigenesis. At least two transcript variants of this gene have been found, but the full-length nature of only one of them has been determined.

Immunogen

KLH-conjugated linear peptide corresponding to human Cathepsin Z near the C-terminus.

Epitope: Near C-terminus

Other Notes

Concentration: Please refer to lot specific datasheet.

Physical form

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Quality

Evaluated by Western Blotting in human liver tissue lysate.

Western Blotting Analysis: 2.0 µg/mL of this antibody detected Cathepsin Z in 10 µg of human liver tissue lysate.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Target description

~33 kDa observed. (Pungecar, J., et al. (2000). PMID: 10653163)